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Chemical Structure : R-10015
CAS No.: 2097938-51-5
Catalog No.: PC-60271Not For Human Use, Lab Use Only.
R-10015 (R10015) is a potent, selective inhibitor of human LIMK1 with IC50 of 38 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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R-10015 (R10015) is a potent, selective inhibitor of human LIMK1 with IC50 of 38 nM.
R-10015 exhibits good selectivity, with off-target inhibition of only LRRK2 and p70S6K (≥90% inhibition at 1 uM) and moderate inhibition of PKA (76%), ROCK2 (70%), and FLT3 (68%).
R-10015 blocks HIV-1 viral DNA synthesis, nuclear migration, and virion release.
R-10015 has broad-spectrum antiviral effect and inhibits multiple viruses, including EBOV, RVFV, VEEV, and HSV-1.
| M.Wt | 410.86 | |
| Formula | C20H19ClN6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Methyl 2-(1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl) piperidin-4-yl)-1H-benzo[d]imidazole-5-carboxylate |
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1. Yi F, et al. J Virol. 2017 Jun 9;91(13). pii: e02418-16.
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