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R-999636

Chemical Structure : R-999636

CAS No.: 90833-53-7

R-999636 (R999636)

Catalog No.: PC-61806Not For Human Use, Lab Use Only.

R-999636 is a small molecule inhibitor that effectively inhibits the β-catenin/Tcf4 interaction with Ki of 8.8 uM in FP assay.

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    Biological Activity

    R-999636 is a small molecule inhibitor that effectively inhibits the β-catenin/Tcf4 interaction with Ki of 8.8 uM in FP assay.
    R-999636 displays 5.8-fold and 7.8-fold selectivity over β-catenin/E-cadherin and β-catenin/APC interactions, respectively.

    Physicochemical Properties

    M.Wt 395.239
    Formula C21H12Cl2N2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2,3-bis(4-chlorophenyl)quinoxaline-6-carboxylic acid

    References

    1. Zhang M, et al. ACS Med Chem Lett. 2013 Jan 8;4(2):306-11.

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