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Chemical Structure : R788 disodium salt
CAS No.: 1025687-58-4
Catalog No.: PC-43348Not For Human Use, Lab Use Only.
Fostamatinib (R788 disodium salt) is a prodrug of the active metabolite R406, which is a potent, ATP-competitive inhibitor of Syk kinase with Ki/IC50 of 30/41 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $478 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Fostamatinib (R788 disodium salt) is a prodrug of the active metabolite R406, which is a potent, ATP-competitive inhibitor of Syk kinase with Ki/IC50 of 30/41 nM.
Fostamatinib dose-dependently inhibits anti-IgE-mediated CHMC degranulation with an EC50 of 56 nM, inhibits all phosphorylation events downstream of Syk signaling; specifically inhibits FcγR signaling in human mast cells, macrophages, and neutrophils.
R788 can inhibit local inflammatory injury mediated by immune complexes; reduces immune complex-mediated inflammation in arthritis models.
| M.Wt | 624.4232 | |
| Formula | C23H24FN6Na2O9P | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one, 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-, sodium salt (1:2) |
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1. Braselmann S, et al. J Pharmacol Exp Ther. 2006 Dec;319(3):998-1008.
2. Chen L, et al. Blood. 2008 Feb 15;111(4):2230-7.
3. Suljagic M, et al. Blood. 2010 Dec 2;116(23):4894-905.
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