Chemical Structure : RA-NSP2-1
CAS No.:
RA-NSP2-1
Catalog No.: PC-25135Not For Human Use, Lab Use Only.
RA-NSP2-1 is a first-in-class, specific inhibitor of chikungunya virus (CHIKV) nsP2 RNA helicase (nsP2hel) with IC50 of 130 nM against unwindase activity of nsP2.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
RA-NSP2-1 is a first-in-class, specific inhibitor of chikungunya virus (CHIKV) nsP2 RNA helicase (nsP2hel) with IC50 of 130 nM against unwindase activity of nsP2.
RA-NSP2-1 inhibits nsP2 helicase with IC50 of 0.84 uM for ATPase activity.
RA-NSP2-1 has a high selectivity for CHIKV over other RNA viruses and for nsP2hel over other RNA helicases.
RA-NSP2-1 inhibits viral replication with IC50 of 0.1 uM in the CHIKV-nLuc viral replication assays.
RA-NSP2-1 is a powerful tool to probe the dynamic motor function of CHIKV viral RNA helicase.
Physicochemical Properties
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M.Wt
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474.66
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Formula
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C26H38N2O4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(R)-(4-((1,1-dioxido-1,2-thiazinan-2-yl)methyl)-1-oxa-9-azaspiro[5.5]undecan-9-yl)(1-phenylcyclopentyl)methanone
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References
1. Muthu Ramalingam B, et al. ACS Infect Dis. 2025 Jul 18. doi: 10.1021/acsinfecdis.5c00351.
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