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Chemical Structure : RA 839
Catalog No.: PC-60871Not For Human Use, Lab Use Only.
A noncovalent small molecule binder to Keap1 (Kd=6 uM) and selective activator of Nrf2 signaling.
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A noncovalent small molecule binder to Keap1 (Kd=6 uM) and selective activator of Nrf2 signaling; binds noncovalently to the Nrf2-interacting kelch domain of Keap1, significantly regulates 105 probe sets in bone marrow-derived macrophages at 10 uM; prevents the induction of both iNOS expression and nitric oxide release in response to lipopolysaccharides in macrophages; acutely induces Nrf2 target gene expression in liver in mice.
| M.Wt | 452.569 | |
| Formula | C25H28N2O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Winkel AF, et al. J Biol Chem. 2015 Nov 20;290(47):28446-55.
2. Nasiri HR, et al. Bioorg Med Chem Lett. 2016 Jan 15;26(2):526-529.
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