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Chemical Structure : RAD51 inhibitor B02
CAS No.: 1290541-46-6
Catalog No.: PC-62842Not For Human Use, Lab Use Only.
RAD51 inhibitor B02 is a small molecule that specifically inhibits the DNA strand exchange activity of human RAD51 with IC50 of 27.4 uM, disrupts RAD51 binding to DNA, inhibits HR and increases cell sensitivity to DNA damage.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 100 mg | $498 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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RAD51 inhibitor B02 is a small molecule that specifically inhibits the DNA strand exchange activity of human RAD51 with IC50 of 27.4 uM, disrupts RAD51 binding to DNA, inhibits HR and increases cell sensitivity to DNA damage.
RAD51 inhibitor B02 increases apoptosis and reduces viability of multiple myeloma cells.
RAD51 inhibitor B02 enhances the effect of cisplatin on triple-negative breast cancer cells in a mouse xenograft model.
| M.Wt | 339.4 | |
| Formula | C22H17N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
3-(phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone |
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1. Huang F, et al. J Med Chem. 2012 Apr 12;55(7):3011-20.
2. Huang F, et al. ACS Chem Biol. 2011 Jun 17;6(6):628-35.
3. Huang F, et al. PLoS One. 2014 Jun 27;9(6):e100993.
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