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Chemical Structure : RAF-IN-10n
CAS No.: 950736-05-7
Catalog No.: PC-45437Not For Human Use, Lab Use Only.
A highlt potent and selective BRAF/CRAF inhibitor with IC50 of 24/25 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $280 | In stock | |
| 50 mg | $760 | In stock | |
| 100 mg | $1200 | In stock |
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A highlt potent and selective BRAF/CRAF inhibitor with IC50 of 24/25 nM, respectively; displays moderate selectivity over p38α (IC50=216 nM) and CAMKII (IC50=822 nM), high selectivity over CDK2, CDK4, PKCa, IKKb, JNK1, MK2, PKA, Src, MKK6, PLK1, p70S6K, PI3 Ka, and PDK1 (IC50>2 uM).
| M.Wt | 515.529 | |
| Formula | C29H24F3N5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 53 mg/mL |
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| Chemical Name/SMILES |
Benzamide, N-[3-[3-[4-[(dimethylamino)methyl]phenyl]pyrazolo[1,5-a]pyrimidin-7-yl]phenyl]-3-(trifluoromethyl)- |
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1. Berger DM, et al. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6519-23.
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