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Chemical Structure : RBN-2397
CAS No.: 2381037-82-5
Catalog No.: PC-72334Not For Human Use, Lab Use Only.
RBN-2397 (Atamparib, RBN2397) is a potent, selective, orally active NAD+ competitive inhibitor of PARP7 with IC50 of <3 nM and Kd of <1 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $438 | In stock | |
| 50 mg | $988 | In stock | |
| 100 mg | $1680 | In stock | |
| 1 g | Get quote |
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RBN-2397 (Atamparib, RBN2397) is a potent, selective, orally active NAD+ competitive inhibitor of PARP7 with IC50 of <3 nM and Kd of <1 nM.
RBN-2397 restores cytosolic nucleic acid sensing and blocks cell proliferation in a human lung cancer cell line.
BN-2397 causes complete regressions in human NSCLC NCI-H1373 xenografts and dose-dependent pharmacodynamic effects. RBN-2397 induces tumor-specific adaptive immune memory in CT26 syngeneic model with durable complete responses.
| M.Wt | 523.44 | |
| Formula | C20H23F6N7O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-5-((1-(3-oxo-3-(4-(5-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)propoxy)propan-2-yl)amino)-4-(trifluoromethyl)pyridazin-3(2H)-one |
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1. Joseph M Gozgit, et al. Cancer Cell. 2021 Sep 13;39(9):1214-1226.e10.
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