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RES-701-3

Chemical Structure : RES-701-3

CAS No.: 151309-36-3

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RES-701-3

Catalog No.: PC-24438Not For Human Use, Lab Use Only.

RES-701-3 is a potent, selective antagonist of endothelin type B receptor (ETB receptor) with IC50 of 31.5 nM, with no activity against ETA. RES-701-3 functions as an inverse agonist.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

RES-701-3 is a potent, selective antagonist of endothelin type B receptor (ETB receptor) with IC50 of 31.5 nM, with no activity against ETA. RES-701-3 functions as an inverse agonist.

Physicochemical Properties

M.Wt 2059.2
Formula C103H115N23O24
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N(1)Gly-DL-Asn-DL-Trp-DL-His-Gly-DL-Thr-DL-Ser-DL-Pro-DL-Asp(1)-DL-Trp-DL-Phe-DL-Phe-DL-Asn-DL-Tyr-DL-Tyr-DL-Trp-OH

References

1. Pagotto U, et al. J Clin Invest. 1995 Oct;96(4):2017-25.

2. Hay DW, et al. Br J Pharmacol. 1996 Jul;118(5):1209-17.

3. Ogawa, T. et al. J. Antibiot. 48, 1213–1220 (1995).

4. Shihoya W, et al. Nat Commun. 2025 Apr 22;16(1):3446.

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