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Chemical Structure : RET-IN-23c
Catalog No.: PC-62829Not For Human Use, Lab Use Only.
RET-IN-23c is a potent and selective RET kinase inhibitor with IC50 of 61.2 nM, shows no significant inhibitory effect against VEGFR-2 and KDR.
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RET-IN-23c is a potent and selective RET kinase inhibitor with IC50 of 61.2 nM, shows no significant inhibitory effect against VEGFR-2 and KDR; inhibits the phosphorylation of RET and the phosphorylation of STAT3 and AKT; exhibits antiproliferative effects against BaF3/CCDC6-RET cells with IC50 of 433 nM.
| M.Wt | 288.311 | |
| Formula | C13H16N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Wang C, et al. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2544-2548.
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