Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Find Your Distributors

Select Your Country or Region

 $ USD

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-Others-Amyloids-RH01386
RH01386

Chemical Structure : RH01386

CAS No.: 301177-36-6

Add to Favorites

RH01386 (ZPD-2, RH 01386)

Catalog No.: PC-62381Not For Human Use, Lab Use Only.

RH01386 (ZPD-2) is a small molecule that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death, also is a small molecule inhibitor of α-Synuclein (α-Syn) aggregation, inhibits the aggregation of wild-type α-Syn and the A30P and H50Q familial variants in vitro.

Packing Price Stock Quantity
5 mg $238 In stock
10 mg $388 In stock
25 mg $598 In stock
50 mg Get quote
100 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

RH01386 (ZPD-2) is a small molecule that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death, also is a small molecule inhibitor of α-Synuclein (α-Syn) aggregation, inhibits the aggregation of wild-type α-Syn and the A30P and H50Q familial variants in vitro.
RH01386 (ZPD-2) increases the survival of human primary β cells and rodent β cell lines subjected to ER stressors including palmitate; also restores ER stress-impaired glucose-stimulated insulin secretion responses.
ZPD-2 inhibits the aggregation of wild-type (WT) α-Syn, the A30P and H50Q familial mutants, being active against the seeded polymerization of different α-Syn strains.
ZPD-2 prevents the spreading of α-Syn seeds in protein misfolding cyclic amplification assays.
ZPD-2 is active against different α-Syn strains and blocks their seeded polymerization.
ZPD-2 reduces the number of α-Syn inclusions and decreases synuclein-induced DA neurons degeneration in two different PD Caenorhabditis elegans models that express α-Syn either in muscle or in dopaminergic (DA) neurons.

Physicochemical Properties

M.Wt 424.398
Formula C18H15F3N4O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-cyclohexyl-2-((2-nitro-4-(trifluoromethyl)phenyl)thio)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

References

1. Tran K, et al. ACS Chem Biol. 2014 Dec 19;9(12):2796-806.
2. Pena-Diaz S., et al. Front. Mol. Neurosci. 2019;12:306.

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

Get Quote

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • Additional Information: