Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : RI173
CAS No.: 729-46-4
Catalog No.: PC-47067Not For Human Use, Lab Use Only.
RI173 is a potent, covalent, triple-acting inhibitor of SARS-CoV-2 protease Mpro, PLpro and human cathepsin L with IC50 of 0.6 uM, 0.2 uM and 1.7 uM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $198 | In stock | |
| 50 mg | $348 | In stock | |
| 100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
RI173 is a potent, covalent, triple-acting inhibitor of SARS-CoV-2 protease Mpro, PLpro and human cathepsin L with IC50 of 0.6 uM, 0.2 uM and 1.7 uM, respectively.
RI173 covalently reacts to the active cysteine residue of SARS-CoV-2 Mpro (Cys 145) and Plpro (Cys111), exhibits 10-fold more potent than disulfiram against SARS-CoV-2 protease.
RI173 exhibits antiviral activity in a narrow range from approximately 100 to 200 nM in SARS-CoV-2 infectivity cells-based assays。
RI173 also shows greater antiviral effect and less toxicitythan disulfiram.
| M.Wt | 324.490 | |
| Formula | C10H16N2O2S4 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
morpholine-4-carbothioic dithioperoxyanhydride |
|
1. Meewan I, et al. Pharmaceuticals (Basel). 2022 Jun 13;15(6):744.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
