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RIPGBM

Chemical Structure : RIPGBM

CAS No.: 355406-76-7

RIPGBM (RIPK2 inhibitor RIPGBM)

Catalog No.: PC-36132Not For Human Use, Lab Use Only.

RIPGBM is a cell type-selective, small molecule inducer of apoptosis in GBM cancer stem cells (CSCs) with EC50 of 220 nM (GBM 1 cells).

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Biological Activity

RIPGBM is a cell type-selective, small molecule inducer of apoptosis in GBM cancer stem cells (CSCs) with EC50 of 220 nM (GBM 1 cells).
RIPGBM is converted to an apoptosis-inducing derivative (cRIPGBM/RIPGBM-18) selectively in GBM CSCs.
cRIPGBM induces apoptosis in GBM CSCs by interacting with RIPK2.
RIPGBM significantly suppress tumor formation in vivo in orthotopic intracranial GBM CSC tumor xenograft mouse model.

Physicochemical Properties

M.Wt 428.463
Formula C26H21FN2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(3-(benzylamino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-N-(4-fluorobenzyl)acetamide

References

1. Lucki NC, et al. Proc Natl Acad Sci U S A. 2019 Mar 7. pii: 201816626. doi: 10.1073/pnas.1816626116.

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