Chemical Structure : RIPK1 inhibitor 13c
CAS No.:
3026543-19-8
RIPK1 inhibitor 13c
Catalog No.: PC-24510Not For Human Use, Lab Use Only.
RIPK1 inhibitor 13c is a potent, selective RIPK1 inhibitor with IC50 of 59.8 nM and Kd of 3.5 nM, effectively prevented the necroptosis (HT-29, EC50=4.58 nM) by inhibiting phosphorylation of RIPK1/RIPK3/MLKL single pathway.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
RIPK1 inhibitor 13c is a potent, selective RIPK1 inhibitor with IC50 of 59.8 nM and Kd of 3.5 nM, effectively prevented the necroptosis (HT-29, EC50=4.58 nM) by inhibiting phosphorylation of RIPK1/RIPK3/MLKL single pathway.
RIPK1 inhibitor 13c displays 486-fold selectivity toward RIPK1 over RIPK3, and no activity against MLKL.
RIPK1 inhibitor 13c inhibits TSZ-induced necroptosis in HT-29 cells, dose-dependently inhibits the phosphorylation of RIPK1 and RIPK3 13c at 3 nM and subsequently inhibits the phosphorylation of downstream MLKL at 30 nM.
13c (300 nM) completely inhibits the phosphorylation of RIPK1, RIPK3, and MLKL.
13c could dose-dependentlythe reduced concentrations of proinflammatory cytokines IL-6 in mice.
Physicochemical Properties
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M.Wt
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553.54
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Formula
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C28H26F3N5O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-Amino-1-((3-methyloxetan-3-yl)methyl)-3-(1-(2-(3-(trifluoromethoxy)phenyl) acetyl)indolin-5-yl)-1,6-dihydro-7H-pyrrolo [2,3-d]pyridazin-7-one
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References
1. Zhang C, et al. Eur J Med Chem. 2024 Feb 5;265:116076.
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