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Chemical Structure : RN-1 dihydrochloride
CAS No.: 1781835-13-9
Catalog No.: PC-61643Not For Human Use, Lab Use Only.
RN-1 dihydrochloride is a potent, irreversible, brain-penetrant inhibitor of LSD1 with IC50 of 70 nM.
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|---|---|---|---|
| 5 mg | $138 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
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| 100 mg | Get quote |
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RN-1 dihydrochloride is a potent, irreversible, brain-penetrant inhibitor of LSD1 with IC50 of 70 nM.
RN-1 dihydrochloride shows much less effectivity against MAO-A and MAO-B (IC50=0.51 and 2.8 uM, respectively).
RN-1 dihydrochloride abolishes long-term memory formation without affecting short-term memory in a mouse model.
RN-1 dihydrochloride also induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice.
| M.Wt | 452.42 | |
| Formula | C23H29N3O2.2HCl | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(4-methyl-1-piperazinyl)-2-[[(1R*,2S*)-2-[4-phenylmethoxy)phenyl]cyclopropyl]amino]ethanone dihydrochloride |
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1. Neelamegam R, et al. ACS Chem Neurosci. 2012 Feb 15;3(2):120-128.
2. Cui S, et al. Blood. 2015 Jul 16;126(3):386-96.
3. Rivers A, et al. Haematologica. 2016 Jun;101(6):688-97.
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