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Chemical Structure : RO 28-2653
Catalog No.: PC-63178Not For Human Use, Lab Use Only.
RO 28-2653 is a potent, selective and orally active matrix-metalloproteinases (MMPs) MMP2, MMP9 and MMP14 inhibitor with IC50 of 10, 12 and 10 nM, shows no activity against MMP3 and MMP1 (IC50>1 uM).
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RO 28-2653 is a potent, selective and orally active matrix-metalloproteinases (MMPs) MMP2, MMP9 and MMP14 inhibitor with IC50 of 10, 12 and 10 nM, shows no activity against MMP3 and MMP1 (IC50>1 uM).
RO 28-2653 reduces the growth of tumors induced by the inoculation of different cell lines producing MMPs and inhibits the tumor-promoting effect of fibroblasts on breast adenocarcinoma cells.
RO 28-2653 reduces tumor growth and prolongs survival in a prostate cancer standard rat model.
| M.Wt | 485.5 | |
| Formula | C26H23N5O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Abramjuk C, et al. Anticancer Drugs. 2005 Sep;16(8):855-61.
2. Maquoi E, et al. Clin Cancer Res. 2004 Jun 15;10(12 Pt 1):4038-47.
3. Mangoldt D, et al. Apoptosis. 2002 Jun;7(3):217-20.
4. Lein M, et al. Oncogene. 2002 Mar 27;21(13):2089-96.
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