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Chemical Structure : RO 5256390
Catalog No.: PC-61071Not For Human Use, Lab Use Only.
A highly potent, selective and orally bioavailable trace amine-associated receptor 1 (TRRA1) full agonist with EC50 of 18 nM, >500-fold selectivity over human adrenergic α2A receptor.
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A highly potent, selective and orally bioavailable trace amine-associated receptor 1 (TRRA1) full agonist with EC50 of 18 nM, >500-fold selectivity over human adrenergic α2A receptor; blocks psychostimulant-induced hyperactivity and produces a brain activation pattern reminiscent of the antipsychotic drug olanzapine in vivo, does not induce catalepsy or weight gain.
| M.Wt | 218.3 | |
| Formula | C13H18N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Revel FG, et al. Mol Psychiatry. 2013 May;18(5):543-56.
2. Pei Y, et al. Neuropsychopharmacology. 2014 Sep;39(10):2299-308.
3. Galley G, et al. ACS Med Chem Lett. 2015 Dec 30;7(2):192-7.
4. Ferragud A, et al. Neuropsychopharmacology. 2017 Jun;42(7):1458-1470.
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