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ROC-325

Chemical Structure : ROC-325

CAS No.: 1859141-26-6

ROC-325 (ROC 325;ROC325)

Catalog No.: PC-60599Not For Human Use, Lab Use Only.

ROC-325 (ROC 325, ROC325) is a novel, orally available inhibitor of lysosomal-mediated autophagy.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ROC-325 (ROC 325, ROC325) is a novel, orally available inhibitor of lysosomal-mediated autophagy.
ROC-325 exhibits superior in vitro anticancer effects compared with the existing autophagy inhibitor hydroxychloroquine (HCQ) in different cancer cell lines, including accumulation of autophagosomes with undegraded cargo, lysosomal deacidification, p62 stabilization, and disruption of autophagic flux.
ROC-325 antagonizes RCC growth and survival in an ATG5/7-dependent manner, induces apoptosis and exhibited favorable selectivity.
ROC-325 significantly more effective at inhibiting tumor progression than HCQ, and inhibited autophagy in vivo.

Physicochemical Properties

M.Wt 503.061
Formula C28H27ClN4OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-((2-((2-((7-chloroquinolin-4-yl)amino)ethyl)(methyl)amino)ethyl)amino)-4-methyl-9H-thioxanthen-9-one

References

1. Carew JS, et al. Clin Cancer Res. 2017 Jun 1;23(11):2869-2879.

2. Carew JS, et al. Autophagy. 2017 Apr 3;13(4):765-766.

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