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Chemical Structure : ROCK inhibitor 23
Catalog No.: PC-49062Not For Human Use, Lab Use Only.
ROCK inhibitor 23 is a potent, selective, and brain-penetrant Rho kinase (ROCK) inhibitor with IC50 of 6 nM.
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ROCK inhibitor 23 is a potent, selective, and brain-penetrant Rho kinase (ROCK) inhibitor with IC50 of 6 nM.
ROCK inhibitor 23 could be dosed orally in mice with selectivity against other AGC kinases, including protein kinase G (PKG).
ROCK inhibitor 23 demonstrated a robust pharmacodynamic (PD) effect by the inhibition of ROCK-mediated substrate (MYPT1) phosphorylation (IC50=4 nM).
| M.Wt | 372.444 | |
| Formula | C20H25FN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tammy Ladduwahetty, et al. J Med Chem. 2022 Jul 11. doi: 10.1021/acs.jmedchem.2c00474.
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