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Chemical Structure : RORγt inverse agonist 22
Catalog No.: PC-35413Not For Human Use, Lab Use Only.
RORγt inverse agonist 22 is a potent, subtype selective RORγt inverse agonist with binding IC50 of 18 nM, displays >192-fold selectivity over RORα and RORβ.
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RORγt inverse agonist 22 is a potent, subtype selective RORγt inverse agonist with binding IC50 of 18 nM, displays >192-fold selectivity over RORα and RORβ.
RORγt inverse agonist 22 exhibits cellular potency in RORγt reporter gene assays with IC50 of 13 nM, also shows >250-fold selectivity over a panel of 20 nuclear receptors。
RORγt inverse agonist 22 demonstrates in vivo potency to suppress the transcriptional activity of RORγt in a mouse PD model upon oral administration.
| M.Wt | 489.551 | |
| Formula | C23H25F2N3O5Si | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Shirai J, et al. Bioorg Med Chem. 2018 Jan 15;26(2):483-500.
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