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Chemical Structure : RORγt inverse agonist 32
Catalog No.: PC-35570Not For Human Use, Lab Use Only.
RORγt inverse agonist 32 is a potent, orally bioavailable inverse agonist of RORγt with IC50 of 9 nM in SPA binding assays.
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RORγt inverse agonist 32 is a potent, orally bioavailable inverse agonist of RORγt with IC50 of 9 nM in SPA binding assays; inhibits IL-17 production from human primary TH17 cells with IC50 of 57 nM; also exhibits favorable PK in rodents.
| M.Wt | 515.574 | |
| Formula | C24H22FN3O5S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Narjes F, et al. J Med Chem. 2018 Aug 10. doi: 10.1021/acs.jmedchem.8b00783.
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