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Chemical Structure : RQ-00203078
CAS No.: 1254205-52-1
Catalog No.: PC-60787Not For Human Use, Lab Use Only.
A potent, selective and orally available TRPM8 channel inhibitor with IC50 of 8.3 nM (hTRPM8).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $345 | In stock | |
| 100 mg | $945 | In stock | |
| 500 mg | Get quote |
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A potent, selective and orally available TRPM8 channel inhibitor with IC50 of 8.3 nM (hTRPM8); inhibits rTRPM8 wiht IC50 of 5.8 nMdisplays no significant activities against TRPA1, TRPV4 and TRPV1 (IC50>3 uM); demonstrates excellent in vivo activity in a dose dependent manner with an ED50 value of 0.65 mg/kg in the icilin-induced wet-dog shakes model in rats; also reduces the invasion potential of oral squamous carcinoma cell lines.
| M.Wt | 554.844 | |
| Formula | C21H13ClF6N2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-(trifluoromethoxy)benzyl)sulfamoyl)benzoic acid |
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1. Okamoto Y, et al. Int J Oncol. 2012 May;40(5):1431-40.
2. Ohmi M, et al. Bioorg Med Chem Lett. 2014 Dec 1;24(23):5364-8.
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