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RSK2-IN-20

Chemical Structure : RSK2-IN-20

CAS No.: 1627136-55-3

RSK2-IN-20

Catalog No.: PC-62854Not For Human Use, Lab Use Only.

RSK2-IN-20 is a potent, selective, and durable inhibitpr of RSK2 with IC50 of 47 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

RSK2-IN-20 is a potent, selective, and durable inhibitpr of RSK2 with IC50 of 47 nM; shows high selectivity over NEK2, PLK1; potently inhibits MSK1 autophosphorylation in cells, and has no significant effect on a panel of 18 additional kinases.

Physicochemical Properties

M.Wt 402.414
Formula C21H18N6O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(E)-2-(1H-1,2,4-triazol-1-yl)-3-(3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl)acrylonitrile

References

1. Krishnan S, et al. J Am Chem Soc. 2014 Sep 10;136(36):12624-30.

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