Chemical Structure : RSP1141
CAS No.:
3119328-25-2
RSP1141
(RSP-1141)
Catalog No.: PC-28761Not For Human Use, Lab Use Only.
RSP1141 is a potent, reversible, non-covalent BTK inhibitor with IC50 of 27.9 nM, inhibits CRP-XL-induced platelet aggregation with IC50 of 173.6 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
RSP1141 is a potent, reversible, non-covalent BTK inhibitor with IC50 of 27.9 nM, inhibits CRP-XL-induced platelet aggregation with IC50 of 173.6 nM.
RSP1141 inhibited BTK-pY223 (IC50=0.316 uM) and PLCγ2-pY753 (IC50=0.325 uM) in intact platelets.
RSP1141 preferentially blocks the BTK-PLCγ2 node over proximal SFK and SYK in platelets.
RSP1141 retains activity against C481S BTK and acts reversibly after drug washout.
RSP1141 engages the BTK–PLCγ2 node with approximately 10-fold cellular selectivity over proximal GPVI kinases.
RSP1141 suppresses GPVI-mediated Ca2+, granule release, integrin activation and spreading.
RSP1141 delayed FeCl3-induced carotid occlusion at 10 mg/kg (oral) in vivo.
Physicochemical Properties
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M.Wt
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389.41
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Formula
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C22H19N3O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3H-imidazo[4,5-b]pyridin-2-yl)-6-ethylbenzene-1,3-diol
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References
1. Kim T, et al. Life Sci. 2026 Nov 10:124772. doi: 10.1016/j.lfs.2026.124772.
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