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Chemical Structure : RTI-7470-44
Catalog No.: PC-72353Not For Human Use, Lab Use Only.
RTI-7470-44 is a potent, selective human trace amine-associated receptor subtype 1 (hTAAR1) inhibitor with IC50 of 8.4 nM in vitro cAMP functional assay.
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RTI-7470-44 is a potent, selective human trace amine-associated receptor subtype 1 (hTAAR1) antagonist with IC50 of 8.4 nM in vitro cAMP functional assay.
RTI-7470-44 exhibits a Ki of 0.3 nM in a radioligand binding assay, and shows species selectivity (>90-fold) for hTAAR1 over the rat and mouse orthologues.
RTI-7470-44 displays good blood–brain barrier permeability, moderate metabolic stability, and a favorable preliminary off-target profile.
RTI-7470-44 increased the spontaneous firing rate of mouse VTA dopaminergic neurons and blocked the effects of the known TAAR1 agonist RO5166017.
| M.Wt | 449.836 | |
| Formula | C19H11ClF3N5OS | |
| Appearance | Solid | |
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1. Ann M Decker, et al. ACS Chem Neurosci. 2022 Mar 24. doi: 10.1021/acschemneuro.2c00086.
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