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Chemical Structure : RTICBM-74
Catalog No.: PC-72728Not For Human Use, Lab Use Only.
RTICBM-74 is a potent, selective, brain-penetrant CB1 negative allosteric modulator (NAM) with IC50 of 23 nM in Ca2+ assays.
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RTICBM-74 is a potent, selective, brain-penetrant CB1 negative allosteric modulator (NAM) with IC50 of 23 nM in Ca2+ assays.
RTICBM-74 displays excellent half-life and low clearance against rat liver microsomes and hepatocytes, and excellent brain penetrance in rats.
RTICBM-74 specifically reduces alcohol intake across a range of doses in male or female Wistar or Long-Evans rats, reduces alcohol intake and does not affect locomotion or sucrose self-administration.
| M.Wt | 340.782 | |
| Formula | C19H14ClFN2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nguyen T, et al. J Med Chem. 2017 Sep 14;60(17):7410-7424.
2. Lovelock DF, et al. J Pharmacol Exp Ther. 2022 Mar;380(3):153-161.
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