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Chemical Structure : RWJ-56110
Catalog No.: PC-61304Not For Human Use, Lab Use Only.
RWJ-56110 is a potent, selective, peptide-mimetic PAR-1 antagonist with binding IC50 of 0.44 uM, with no effect on PAR-2, PAR-3, or PAR-4.
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RWJ-56110 is a potent, selective, peptide-mimetic PAR-1 antagonist with binding IC50 of 0.44 uM, with no effect on PAR-2, PAR-3, or PAR-4.
RWJ-56110 inhibits thrombin activates human platelets aggregation with IC50 of 0.34 uM.
RWJ-56110 also blocks angiogenesis association with endothelial cell growth suppression and induction of apoptosis.
| M.Wt | 863.65 | |
| Formula | C41H43Cl2F2N7O3.2HC | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Andrade-Gordon P, et al. Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12257-62.N9691
2. Zhang HC, et al. Bioorg Med Chem Lett. 2001 Aug 20;11(16):2105-9.
3. Tanaka M, et al. J Pharmacol Sci. 2016 Jul;131(3):162-71.
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