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Chemical Structure : RX-5902
CAS No.: 888478-45-3
Catalog No.: PC-73060Not For Human Use, Lab Use Only.
RX-5902 (Supinoxin, RX5902) is a small molecule inhibitor of phosphorylated-p68 RNA helicase (P-p68) and attenuates nuclear shuttling of β-catenin.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $398 | In stock | |
| 50 mg | $898 | In stock | |
| 100 mg | $1380 | In stock | |
| 1 g | Get quote |
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RX-5902 (Supinoxin, RX5902) is a small molecule inhibitor of phosphorylated-p68 RNA helicase (P-p68) and attenuates nuclear shuttling of β-catenin.
RX-5902 directly binds to Y593 phospho-p68 RNA helicase, exhibits strong growth inhibition in various human cancer cell lines with IC50 values ranging between 10 and 20 nM.
RX-5902 inhibited the β-catenin dependent ATPase activity of p68 RNA helicase, downregulates the expression of certain genes in β-catenin pathway, such as c-Myc, cyclin D1 and p-c-Jun.
RX-5902 inhibits β-catenin signaling and demonstrates anti-tumor activity in triple-negative breast cancer (TNBC) in vivo.
| M.Wt | 441.463 | |
| Formula | C22H24FN5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(3,5-Dimethoxyphenyl)-4-[(6-fluoro-2-methoxyquinoxalin-3-yl)aminocarbonyl] piperazine |
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1. Capasso A, et al. Mol Cancer Ther. 2019 Sep 5. pii: molcanther.1334.2018. doi: 10.1158/1535-7163.MCT-18-1334.
2. Kost GC, et al. J Cell Biochem. 2015 Aug;116(8):1595-601.
3. Ali W, et al. Prog Biophys Mol Biol. 2018 Dec;140:79-89.
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