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Chemical Structure : Rac1-IN-1
Catalog No.: PC-61469Not For Human Use, Lab Use Only.
Rac1-IN-1 is a selective small molecule Rac1 inhibitor that blocks Rac1-PAK1 complex formation with IC50 of 95±21 nM.
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Rac1-IN-1 is a selective small molecule Rac1 inhibitor that blocks Rac1-PAK1 complex formation with IC50 of 95±21 nM.
Rac1-IN-1 diminishes the EGF-induced Rac1 activation in CD18/HPAF cells with EC50 of 8.3±1.7 uM, has no inhibitory effect on either Cdc42 or RhoA in CD18/HPAF cells.
Rac1-IN-1 shows a 50% and 20% decrease in proliferation for AsPC-1 and CD18/HPAF cells at 25 uM.
Rac1-IN-1 also reduces migration of pancreatic cancer cells.
| M.Wt | 350.33 | |
| Formula | C19H14N2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Arnst JL, et al. Oncotarget. 2017 May 23;8(21):34586-34600.
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