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Rac1-IN-6

Chemical Structure : Rac1-IN-6

CAS No.: 701223-06-5

Rac1-IN-6

Catalog No.: PC-61470Not For Human Use, Lab Use Only.

Rac1-IN-6 is a selective small molecule Rac1 inhibitor that blocks Rac1-PAK1 complex formation with IC50 of 88±48 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Rac1-IN-6 is a selective small molecule Rac1 inhibitor that blocks Rac1-PAK1 complex formation with IC50 of 88±48 nM.
    Rac1-IN-6 diminishes the EGF-induced Rac1 activation in CD18/HPAF cells with EC50 of 22.4±3.2 uM, has no inhibitory effect on either Cdc42 or RhoA in CD18/HPAF cells.
    Rac1-IN-6 inhibits the proliferation, reduces migration of pancreatic cancer cells.

    Physicochemical Properties

    M.Wt 388.485
    Formula C23H20N2O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-(3,5-dimethylphenyl)-2-(3-(thiophene-2-carbonyl)-1H-indol-1-yl)acetamide

    References

    1. Arnst JL, et al. Oncotarget. 2017 May 23;8(21):34586-34600.

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