Chemical Structure : Rapavir
CAS No.:
Rapavir
(JH-B10)
Catalog No.: PC-24441Not For Human Use, Lab Use Only.
Rapavir (JH-B10) is a novel inhibitor of sodium taurocholate cotransporting polypeptide (NTCP) with potent anti-HBV efficacy, shows inhibitory activity against both TCA-d4 uptake and HBV infection with IC50 of 1.8 nM (TCA-d4), 63 nM (HBeAg), and 22 nM (HBV 3.5-kb RNA), respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Rapavir (JH-B10) is a novel inhibitor of sodium taurocholate cotransporting polypeptide (NTCP) with potent anti-HBV efficacy, shows inhibitory activity against both TCA-d4 uptake and HBV infection with IC50 of 1.8 nM (TCA-d4), 63 nM (HBeAg), and 22 nM (HBV 3.5-kb RNA), respectively.
The inhibitory effect of rapavir is FKBP12-independent.
Rapavir significantly reduced intracellular HBV cccDNA and HBV RNA, along with extracellular HBeAg and HBsAg, in a concentration-dependent manner, exerts its antiviral effect during the HBV infection phase by directly blocking NTCP, rather than impacting the viral replication process.
Rapavir (2 mg/kg body weight, i.p.) demonstrated the robust anti-HBV activity in humanized liver-chimeric mice.
Physicochemical Properties
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M.Wt
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Formula
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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