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Chemical Structure : Raptinal
CAS No.: 1176-09-6
Catalog No.: PC-21768Not For Human Use, Lab Use Only.
Raptinal is a small molecule rapid apoptosis inducer, initiates intrinsic pathway caspase-dependent apoptosis in multiple cell lines, also inhibits the activity of caspase-activated Pannexin 1 (PANX1).
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|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
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Raptinal is a small molecule rapid apoptosis inducer, initiates intrinsic pathway caspase-dependent apoptosis in multiple cell lines, also inhibits the activity of caspase-activated Pannexin 1 (PANX1).
Raptinal rapidly trigger apoptosis by promoting the release of cytochrome c from the mitochondria and subsequently activating the intrinsic apoptotic pathway.
Raptinal is very effective at inducing apoptosis in a variety of different cell types in vitro and in vivo.
Raptinal inhibits cleavage-activated PANX1 via a mechanism distinct to other well-described PANX1 inhibitors such as carbenoxolone and trovafloxacin.
Raptinal also interferes with PANX1-regulated apoptotic processes including the release of the 'find-me' signal ATP, the formation of apoptotic cell-derived extracellular vesicles, as well as NLRP3 inflammasome activation.
Raptinal is the first compound that can simultaneously induce apoptosis and inhibit PANX1 channels.
| M.Wt | 386.45 | |
| Formula | C28H18O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
9H,9'H-[9,9'-Bifluorene]-9,9'-dicarbaldehyde |
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1. Palchaudhuri R, et al. Cell Rep. 2015 Dec 1;13(9):2027-36.
2. Heimer S, et al. Cell Death Dis. 2019 Jul 19;10(8):556.
3. Santavanond JP, et al. Cell Death Dis. 2024 Feb 9;15(2):123.
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