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Chemical Structure : RasGRP3 ligand 96
CAS No.: 2229068-13-5
Catalog No.: PC-35300Not For Human Use, Lab Use Only.
RasGRP3 ligand 96 is a potent, selective ligand of Ras guanine-releasing protein 3 (RasGRP3) with Ki of 1.75 nM, showed 73-fold and 45-fold selectivity relative to PKCα and PKCε for in vitro binding activity resepctively.
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| 5 mg | $858 | In stock | |
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RasGRP3 ligand 96 is a potent, selective ligand of Ras guanine-releasing protein 3 (RasGRP3) with Ki of 1.75 nM, shows 73-fold and 45-fold selectivity relative to PKCα and PKCε for in vitro binding activity resepctively.
RasGRP3 ligand 96 induces Ras activation, a downstream response to RasGRP stimulation, with 8-29 fold selectivity relative to PKCδ S299 phosphorylation in intact cells.
| M.Wt | 371.433 | |
| Formula | C21H25NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(E)-(2-(Hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)methylene)-5-oxotetrahydrofuran-2-yl)methyl pivalate |
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1. Ann J, et al. J Med Chem. 2018 Jul 3. doi: 10.1021/acs.jmedchem.8b00661.
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