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Chemical Structure : Rasarfin
Catalog No.: PC-72019Not For Human Use, Lab Use Only.
Rasarfin is a novel dual Ras and ARF6 inhibitor, selectively inhibits small G proteins Ras and ARF6 with IC50 of 7 and 0.7 uM.
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Rasarfin is a novel dual Ras and ARF6 inhibitor, selectively inhibits small G proteins Ras and ARF6 with IC50 of 7 and 0.7 uM.
Rasarfin blocks agonist-mediated internalization of AT1R and other GPCRs.
Rasarfin also potently inhibits agonist-induced ERK1/2 signaling by GPCRs, and MAPK and Akt signaling by EGFR, as well as prevents cancer cell proliferation.
Rasarfin blocks GPCR internalization through inhibition of ARF6, a regulator of CCV-mediated endocytosis, and receptor-mediated MAPK.
| M.Wt | 425.913 | |
| Formula | C23H24ClN3O3 | |
| Appearance | Solid | |
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1. Jenna Giubilaro, et al. Nat Commun. 2021 Aug 3;12(1):4688.
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