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Chemical Structure : Rebimastat
Catalog No.: PC-72039Not For Human Use, Lab Use Only.
Rebimastat (BMS-275291, D2163) is a potent, broad spectrum matrix metalloproteinase (MMPs) inhibitor with potential antineoplastic activity, shows nM potency against MMP-1/2/7/9/14.
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Rebimastat (BMS-275291, D2163) is a potent, broad spectrum matrix metalloproteinases (MMPs) inhibitor with potential antineoplastic activity, shows nM potency against MMP-1/2/7/9/14.
BMS-275291 inhibits tumor growth in a B16BL6 model of experimental metastasis, BMS-275291 treatment results in a dose-dependent reduction in the number of lung metastases.
BMS-275291 also inhibits angiogenesis in a murine angiogenesis model with a dose-dependent inhibition of endothelial cell migration.
Rebimastat (BMS-275291) induces extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis.
| M.Wt | 499.7 | |
| Formula | C23H41N5O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Daniel P Becker, et al. J Med Chem. 2010 Sep 23;53(18):6653-80.
2. Naglich JG, et al. Cancer Res. 2001 Dec 1;61(23):8480-5.
3. Lockhart AC, et al. Clin Cancer Res. 2003 Feb;9(2):586-93.
4. Rizvi NA, et al. Clin Cancer Res. 2004 Mar 15;10(6):1963-70.
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