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Chemical Structure : Refametinib
CAS No.: 923032-37-5
Catalog No.: PC-44028Not For Human Use, Lab Use Only.
Refametinib (BAY 86-97661, RDEA-119) is a potent, non-ATP-competitive, highly selective, allosteric inhibitor of MEK1/2 with IC50 of 19/47 nM respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $238 | In stock | |
| 100 mg | $388 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Refametinib (BAY 86-97661, RDEA-119) is a potent, non-ATP-competitive, highly selective, allosteric inhibitor of MEK1/2 with IC50 of 19/47 nM respectively.
Refametinib inhibits anchorage-dependent growth of human cancer cell lines harboring the gain-of-function V600E BRAF mutant with GI50 of 67-89 nM.
Refametinib exhibits complete suppression of ERK phosphorylation at fully efficacious doses in mice and orally bioactive.
| M.Wt | 572.3372 | |
| Formula | C19H20F3IN2O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 31 mg/mL |
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| Chemical Name/SMILES |
Cyclopropanesulfonamide, N-[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]- |
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1. Iverson C, et al. Cancer Res. 2009 Sep 1;69(17):6839-47.
2. Chang Q, et al. BMC Cancer. 2010 Sep 28;10:515.
3. Schmieder R, et al. Neoplasia. 2013 Oct;15(10):1161-71.
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