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Regdanvimab

Chemical Structure : Regdanvimab

CAS No.:

Regdanvimab (CT-P59)

Catalog No.: PC-38893Not For Human Use, Lab Use Only.

Regdanvimab (Regkirona, CT-P59) is a recombinant human immunoglobulin G1 antibody targeted against SARS-CoV-2 sipke RBD, shows therapeutic effect against SARS-CoV-2 South African variants.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Regdanvimab (Regkirona, CT-P59) is a recombinant human immunoglobulin G1 antibody targeted against SARS-CoV-2 sipke RBD, shows therapeutic effect against SARS-CoV-2 South African variants.
CT-P59 neutralized B.1.1.7 variant to a similar extent as to wild type virus.
CT-P59 showed reduced binding affinity against a RBD (receptor binding domain) triple mutant containing mutations defining B.1.351 (K417N/E484K/N501Y), also showed reduced potency against the SA variant in live virus and pseudovirus neutralization assay systems.
CT-P59 decrease B.1.351 viral load in the upper and lower respiratory tracts, comparable to that observed for the wild type virus.

Isotype: IgG1-lambda.
Anti-[human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein, receptor binding domain (RBD)], humanized and Homo sapiens monoclonal antibody.

Physicochemical Properties

M.Wt
Formula
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

References

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