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Chemical Structure : Regorafenib monohydrate
CAS No.: 1019206-88-2
Catalog No.: PC-42531Not For Human Use, Lab Use Only.
A potent multikinase inhibitor that potently inhibits these endothelial cell kinases in biochemical and cellular kinase phosphorylation assays with nanomolar range (IC50=3-200 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $76 | In stock | |
| 100 mg | $116 | In stock | |
| 200 mg | $208 | In stock |
Bulk size, bulk discount!
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A potent multikinase inhibitor that potently inhibits these endothelial cell kinases in biochemical and cellular kinase phosphorylation assays with nanomolar range (IC50=3-200 nM); inhibits VEGFR1/2/3, PDGFRβ, FGFR1, KIT, RET and B-RAF etc.; exhibits potent dose-dependent TGI in various preclinical human xenograft models in mice; orally active.
Colon Cancer
Approved
| M.Wt | 500.8307 | |
| Formula | C21H17ClF4N4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-, hydrate (1:1) |
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1. Wilhelm SM, et al. Int J Cancer. 2011 Jul 1;129(1):245-55.
2. Mross K, et al. Clin Cancer Res. 2012 May 1;18(9):2658-67.
3. Abou-Elkacem L, et al. Mol Cancer Ther. 2013 Jul;12(7):1322-31.
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