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Chemical Structure : Rencofilstat
Catalog No.: PC-38419Not For Human Use, Lab Use Only.
Rencofilstat (CRV431) is a non-immunosuppressive analogue of cyclosporine A and pan-cyclophilin inhibitor, potently inhibits cyclophilin isoforms A, B, D, and G with IC50 of 1-7 nM.
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Rencofilstat (CRV431) is a non-immunosuppressive analogue of cyclosporine A and pan-cyclophilin inhibitor, potently inhibits cyclophilin isoforms A, B, D, and G with IC50 of 1-7 nM.
Rencofilstat (CRV431) is more than 13 times more potent than the parent compound, cyclosporine A (CsA).
Rencofilstat (CRV431) inhibits liver HBV DNA and HBsAg, reduces liver HBV DNA levels and moderately decreased serum HBsAg levels in HBV transgenic mouse model.
Rencofilstat (CRV431) shows potential as a drug candidate for chronic liver diseases.
| M.Wt | 1303.784 | |
| Formula | C67H122N12O13 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gallay P, et al. PLoS One. 2019 Jun 10;14(6):e0217433.
2. Kuo J, et al. J Pharmacol Exp Ther. 2019 Nov;371(2):231-241.
3. Trepanier DJ, et al. J Pharm Pharm Sci. 2018;21(1s):335s-348s.
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