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Chemical Structure : RepSox
CAS No.: 446859-33-2
Catalog No.: PC-43322Not For Human Use, Lab Use Only.
RepSox (E-616452, SJN-2511) is a potent, selective inhibitor of TGF-β type I receptor ALK5 with Ki of 25 nM, inhibits ALK5 autophosphorylation with IC50 of 4 nM, can replace the central reprogramming factor Sox2 by inducing nanog.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $68 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | Get quote |
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RepSox (E-616452, SJN-2511) is a potent, selective inhibitor of TGF-β type I receptor ALK5 with Ki of 25 nM, inhibits ALK5 autophosphorylation with IC50 of 4 nM, can replace the central reprogramming factor Sox2 by inducing nanog; specifically acts by inhibiting Tgf-β signaling, does not act by inducing Sox2 expression in the target fibroblasts; efficiently replaces transgenic Sox2 in the absence of VPA and c-Myc, as well as in both embryonic and adult fibroblasts; demonstrates effectivity at generating iPSCs.
| M.Wt | 287.3186 | |
| Formula | C17H13N5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 52 mg/mL |
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| Chemical Name/SMILES |
2-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine |
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1. Ichida JK, et al. Cell Stem Cell. 2009 Nov 6;5(5):491-503.
2. Liu X, et al. Nat Cell Biol. 2013 Jul;15(7):829-38.
3. Gellibert F, et al. J Med Chem. 2004 Aug 26;47(18):4494-506.
4. Wu MZ, et al. Cell Res. 2014 Jun;24(6):641-2.
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