Retapamulin (SB275833) |CAS 224452-66-8 Probechem Biochemicals

Chemical Structure : Retapamulin

CAS No.: 224452-66-8

Retapamulin (SB-275833, SB275833)

Catalog No.: PC-45135Not For Human Use, Lab Use Only.

Retapamulin (SB275833) is an pleuromutilin antibiotic, specifically a protein synthesis inhibitor by interacting on the 50S subunit of the bacterial ribosome, binds to both E. coli and S. aureus ribosomes with Kd of 3 nM.

Packing	Price	Stock
50 mg	$98	In stock
100 mg	$138	In stock
250 mg	$218	In stock
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Biological Activity

Retapamulin (SB275833) is an pleuromutilin antibiotic, specifically a protein synthesis inhibitor by interacting on the 50S subunit of the bacterial ribosome, binds to both E. coli and S. aureus ribosomes with Kd of 3 nM.
Retapamulin demonstrates high efficacy against certain Gram-positive bacteria including MRSA.

Physicochemical Properties

M.Wt	517.7635
Formula	C30H47NO4S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	DMSO: ≥ 52 mg/mL
Chemical Name/SMILES	Acetic acid, 2-[[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester

References

1. Goldstein EJ, et al. Antimicrob Agents Chemother. 2006 Jan;50(1):379-81.

2. Jones RN, et al. Antimicrob Agents Chemother. 2006 Jul;50(7):2583-6.

3. Champney WS, et al. Antimicrob Agents Chemother. 2007 Sep;51(9):3385-7.

Retapamulin (SB-275833, SB275833)

Biological Activity

Physicochemical Properties

References

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