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Chemical Structure : Rhosin hydrochloride
CAS No.: 1281870-42-5
Catalog No.: PC-43132Not For Human Use, Lab Use Only.
Rhosin (G04) is a potent, specific RhoA subfamily Rho GTPases inhibitor that specifically binds to RhoA to inhibit GEF reaction of RhoA with Kd of 0.4 uM, does not interact with Cdc42 or Rac1, nor the LARG.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 2 mg | $128 | In stock | |
| 5 mg | $198 | In stock | |
| 10 mg | $328 | In stock | |
| 25 mg | $528 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Rhosin (G04) hydrochloride is a potent, specific RhoA subfamily Rho GTPases inhibitor that specifically binds to RhoA to inhibit GEF reaction of RhoA with Kd of 0.4 uM, does not interact with Cdc42 or Rac1, nor the LARG.
Rhosin specifically inhibits GEF activation of RhoA in vitro and in cells and can potently suppress breast cancer cell proliferation and invasion and induce neurite outgrowth in PC12 cells.
Rhosin strongly inhibits RhoA-GTP formation in NIH 3T3 cells (EC50=10-30 uM), reduces RhoA and p-MLC1 activities of MCF7 cell-derived mammospheres (EC50=30-50 uM).
Rhosin suppresses invasion of mammary epithelial cells, induces neurite outgrowth of PC12 cells in synergy with NGF.
| M.Wt | 394.8575 | |
| Formula | C20H19ClN6O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
D-Tryptophan, 2-(6-quinoxalinylmethylene)hydrazide, hydrochloride (1:1) |
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1. Shang X, et al. Chem Biol. 2012 Jun 22;19(6):699-710.
2. Shang X, et al. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3155-60.
3. Yoon C, et al. Clin Cancer Res. 2016 Feb 15;22(4):971-83.
4. Duan X, et al. Cell Cycle. 2016;15(3):471-7.
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