Ridinilazole | C. difficile inhibitor | Probechem Biochemicals

Chemical Structure : Ridinilazole

CAS No.: 308362-25-6

Ridinilazole (SMT19969)

Catalog No.: PC-22943Not For Human Use, Lab Use Only.

Ridinilazole (SMT19969) is a narrow-spectrum, non-absorbable antimicrobial against Clostridium difficile with MIC of 0.125 to 0.5 ug/ml, MIC90 of 0.25 ug/mL, including ribotype 027 strains.

Packing	Price	Stock
5 mg	$128	In stock
10 mg	$198	In stock
25 mg	$348	In stock
50 mg	$548	In stock
100 mg		Get quote

Get Quotation Now

* Please select Quantity before adding items.

or Bulk Inquiry

Bulk size, bulk discount!

Welcome credit card payment!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Biological Activity

Ridinilazole (SMT19969) is a narrow-spectrum, non-absorbable antimicrobial against Clostridium difficile with MIC of 0.125 to 0.5 ug/ml, MIC90 of 0.25 ug/mL, including ribotype 027 strains.
Ridinilazole (SMT19969) is more active against C. difficile isolates than fidaxomicin (range, 0.06 to 1 μg/ml; MIC90, 0.5 μg/ml) and two to six dilutions lower than either vancomycin or metronidazole.
Ridinilazole (SMT19969) is generally less active against Gram-negative anaerobes, especially the Bacteroides fragilis group species, than vancomycin and metronidazole. SMT19969 showed limited activity against other Gram-positive anaerobes, including Bifidobacteria species, Eggerthella lenta, Finegoldia magna, and Peptostreptococcus anaerobius, with MIC90s of >512, >512, 64, and 64 μg/ml, respectively.

Physicochemical Properties

M.Wt	388.43
Formula	C24H16N6
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,2'-Di(pyridin-4-yl)-1H,1'H-5,5'-bibenzo[d]imidazole

References

1. Sattar A, et al. J Antimicrob Chemother. 2015;70(6):1757-62.

2. Corbett D, et al. J Antimicrob Chemother. 2015;70(6):1751-6.

3. Goldstein EJ, et al. Antimicrob Agents Chemother. 2013 Oct;57(10):4872-6.

Ridinilazole (SMT19969)

Biological Activity

Physicochemical Properties

References

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

Get Quote

* Indicates a Required FieldYour information is safe with us.