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Chemical Structure : Rilpivirine
CAS No.: 500287-72-9
Catalog No.: PC-42661Not For Human Use, Lab Use Only.
Rilpivirine (R278474, TMC278) is a highly potent nonnucleoside inhibitor (NNRTI) of HIV-1 reverse trK7912:M7912anscriptase with IC50 of 0.4 nM for WT HIV-1 in cell-based assay.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $118 | In stock | |
| 50 mg | $188 | In stock | |
| 100 mg | $298 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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Rilpivirine (R278474, TMC278) is a highly potent nonnucleoside inhibitor (NNRTI) of HIV-1 reverse trK7912:M7912anscriptase with IC50 of 0.4 nM for WT HIV-1 in cell-based assay.
Rilpivirine (R278474, TMC278) shows activity against a panel of single and double HIV-1 site-directed mutant (IC50=0.3-2 nM); orally active.
| M.Wt | 366.4185 | |
| Formula | C22H18N6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzonitrile, 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]- |
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1. Janssen PA, et al. J Med Chem. 2005 Mar 24;48(6):1901-9.
2. Das K, et al. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1466-71.
3. Azijn H, et al. Antimicrob Agents Chemother. 2010 Feb;54(2):718-27.
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