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Chemical Structure : Rintodestrant
Catalog No.: PC-38372Not For Human Use, Lab Use Only.
Rintodestrant (G1T48) is a potent, oral selective estrogen receptor degrader (SERD) with EC50 of 0.24 nM (ERα degradation, ICW), competitively binds to and degrades estrogen receptor (ER) and blocks ER signaling in ER-positive breast cancer cells.
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Rintodestrant (G1T48) is a potent, oral selective estrogen receptor degrader (SERD) with EC50 of 0.24 nM (ERα degradation, ICW), competitively binds to and degrades estrogen receptor (ER) and blocks ER signaling in ER-positive breast cancer cells.
| M.Wt | 462.491 | |
| Formula | C26H19FO5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Philippe Aftimos, et al. Cancer Res (2021) 81 (4_Supplement): PS12-04.
2. Kaitlyn J Andreano, et al. Breast Cancer Res Treat. 2020 Apr;180(3):635-646.
3. Xiong R, et al. J Med Chem. 2017;60(4):1325–1342.
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