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Chemical Structure : Riviciclib
CAS No.: 920113-03-7
Catalog No.: PC-61279Not For Human Use, Lab Use Only.
Riviciclib (P276-00 hydrochloride) is a potent CDK inhibitor with IC50 of 79 nM, 63 nM and 20 nM for Cdk4/cyclin D1, Cdk1/cyclin B and Cdk9/cyclin T1, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $188 | In stock | |
| 25 mg | $358 | In stock | |
| 100 mg | Get quote |
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Riviciclib (P276-00 hydrochloride) is a potent CDK inhibitor with IC50 of 79 nM, 63 nM and 20 nM for Cdk4/cyclin D1, Cdk1/cyclin B and Cdk9/cyclin T1, respectively.
Riviciclib (P276-00 hydrochloride) weakly inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk6/cyclin D3 and Cdk7/cyclin H with IC50 of 0.2-3 uM.
Riviciclib (P276-00 hydrochloride) shows potent antiproliferative effects against various human cancer cell lines (IC50=200-800 nM).
Riviciclib (P276-00 hydrochloride) induces G1-G2 arrest, shows antitumor activity on cisplatin-resistant cells and significant in vivo efficacy in tumor models.
| M.Wt | 438.3 | |
| Formula | C21H20ClNO5.HCl | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-(2-chlorophenyl)-5,7-dihydroxy-8-((2R,3S)-2-(hydroxymethyl)-1-methylpyrrolidin-3-yl)-4H-chromen-4-one hydrochloride |
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1. Joshi KS, et al. Mol Cancer Ther. 2007 Mar;6(3):918-25.
2. Joshi KS, et al. Mol Cancer Ther. 2007 Mar;6(3):926-34.
3. Raje N, et al. Leukemia. 2009 May;23(5):961-70.
4. Rathos MJ, et al. J Transl Med. 2012 Aug 8;10:161.
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