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Chemical Structure : Ro 25-1553
Catalog No.: PC-20660Not For Human Use, Lab Use Only.
Ro 25-1553 is a potent, selective VIPR2 agonist and a cyclic peptide analog of vasoactive intestinal peptide (VIP), displaces the radioligand 125I-VIP from rat forebrain membranes with IC50 of 4.98 nM.
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Ro 25-1553 is a potent, selective VIPR2 agonist and a cyclic peptide analog of vasoactive intestinal peptide (VIP), displaces the radioligand 125I-VIP from rat forebrain membranes with IC50 of 4.98 nM.
Ro 25-1553 is 24 to 89 times more potent than VIP as a relaxant of guinea pig trachea.
Ro 25-1553 is inactive in a battery of 40 other binding assays (e.g., muscarinic, histamine, LTs, Ca++, TxA2, endothelin, alpha and beta adrenergic, platelet-activating factor, neurokinins, etc.) at 10 uM.
Ro 25-1553 exhibited potent smooth muscle relaxant activity in vitro.
Ro 25-1553 inhibited pulmonary responses evoked by histamine, leukotriene D4, platelet-activating factor and acetylcholine after in vivo intratracheal administration.
| M.Wt | 3562.05 | |
| Formula | C160H258N46O46 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. O'Donnell M, et al. J Pharmacol Exp Ther. 1994 Sep;270(3):1282-8.
2. O'Donnell M, et al. J Pharmacol Exp Ther. 1994 Sep;270(3):1289-94.
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