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Ro 41-0960

Chemical Structure : Ro 41-0960

CAS No.: 125628-97-9

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Ro 41-0960 (Ro41-0960)

Catalog No.: PC-27912Not For Human Use, Lab Use Only.

Ro 41-0960 is a potent and selective, CNS-penetrant, orally active inhibitor of catechol-O-methyltransferase (COMT), also is a Na+/K+-ATPase inhibitor with IC50 of 17.9 uM and 10.3 uM for purified enzyme and microsomal preparations.

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5 mg $78 In stock
10 mg $118 In stock
25 mg $198 In stock
50 mg $298 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Ro 41-0960 is a potent and selective, CNS-penetrant, orally active inhibitor of catechol-O-methyltransferase (COMT), also is a Na+/K+-ATPase inhibitor with IC50 of 17.9 uM and 10.3 uM for purified enzyme and microsomal preparations.

Physicochemical Properties

M.Wt 277.21
Formula C13H8FNO5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3,4-Dihydroxy-5-nitrophenyl)(2-fluorophenyl)methanone

References

1. Percy E, et al. Br J Pharmacol. 1999 Oct;128(3):774-80.

2. Cruz-Cortés C, et al. ChemMedChem. 2026 Sep 14;21(17):e70442.

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