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Chemical Structure : Ro 46-2005
CAS No.: 150725-87-4
Catalog No.: PC-45639Not For Human Use, Lab Use Only.
Ro 46-2005 is the first synthetic orally active nonpeptide antagonist of endothelin receptor with equipotent potency (IC50=0.2-0.5 uM) for ETA and ETB.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $400 | In stock | |
| 50 mg | $1200 | In stock | |
| 100 mg | Get quote |
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Ro 46-2005 is the first synthetic orally active nonpeptide antagonist of endothelin receptor with equipotent potency (IC50=0.2-0.5 uM) for ETA and ETB; has no effect on plasma concentrations of big ET-1 and only a minor effect on those of ET-3; sufficient to inhibit the pressor effect of the precursor big ET-1 at much lower doses (1 to 10 mg/kg i.v.).
Hypertension
Preclinical
| M.Wt | 473.542 | |
| Formula | C23H27N3O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 28 mg/mL |
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| Chemical Name/SMILES |
Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(3-methoxyphenoxy)-4-pyrimidinyl]- |
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1. Clozel M, et al. Nature. 1993 Oct 21;365(6448):759-61.
2. Breu V, et al. FEBS Lett. 1993 Nov 15;334(2):210-4.
3. Clozel M, et al. J Cardiovasc Pharmacol. 1993;22 Suppl 8:S377-9.
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