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Ro5-4864

Chemical Structure : Ro5-4864

CAS No.: 14439-61-3

Ro5-4864 (4'-Chlorodiazepam;Ro 5-4864;Ro 54864)

Catalog No.: PC-60195Not For Human Use, Lab Use Only.

A potent, selective ligand for the mitochondrial translocator protein 18kDa (TSPO/PBR).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A potent, selective ligand for the mitochondrial translocator protein 18kDa (TSPO/PBR); has proved to be neuroprotective and has become widely used for research into the role of the TSPO protein in neurotoxicity; shows analgesic, antidepressant, cardioprotective, and anti-cancer effects.

Physicochemical Properties

M.Wt 319.185
Formula C16H12Cl2N2O
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

7-Chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one

References

1. File SE, et al. Psychopharmacology (Berl). 1984;82(3):199-202.

2. Sakai M, et al. Eur J Pharmacol. 2006 Nov 21;550(1-3):8-14.

3. Palzur E, et al. Neuroscience. 2016 Aug 4;329:162-70.

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